Largest Biochemical Circuit Built Out of Small Synthetic DNA Molecules
Lulu Qian, Senior Postdoctoral Scholar in Bioengineering, and colleagues including Erik Winfree, Professor of Computer Science, Computation and Neural Systems, and Bioengineering, have built the most complex biochemical circuit ever created from scratch made with DNA-based devices in a test tube that are analogous to the electronic transistors on a computer chip."We're trying to borrow the ideas that have had huge success in the electronic world, such as abstract representations of computing operations, programming languages, and compilers, and apply them to the biomolecular world," says Dr. Qian. [Caltech Press Release]
Converting Heat into Electricity in Space and on Earth - High-Performance Bulk Thermoelectrics
Jeff Snyder, Faculty Associate in Applied Physics and Materials Science, and colleagues have developed a thermoelectric material that might be able to operate off nothing more than the heat of a car's exhaust. "You'll see applications wherever there's a solid-state advantage," Snyder predicts. "One example is the charging system. The electricity to keep your car's battery charged is generated by the alternator, a mechanical device driven by a rubber belt powered by the crankshaft. You've got friction, slippage, strain, internal resistance, wear and tear, and weight, in addition to the mechanical energy extracted to make the electricity. Just replacing that one subsystem with a thermoelectric solution could instantly improve a car's fuel efficiency by 10 percent." [Caltech Press Release]
Stimulating Electrode Array Assists Paraplegic Man to Stand and Move Legs Voluntarily
Joel W. Burdick, Professor of Mechanical Engineering and Bioengineering, and colleagues including Yu-Chong Tai, Professor of Electrical Engineering and Mechanical Engineering, have used a stimulating electrode array to assist a paralyzed man to stand, step on a treadmill with assistance, and, over time, to regain voluntary movements of his limbs. Using a combination of experimentation, computational models of the array and spinal cord, and machine-learning algorithms, Professor Burdick and his colleagues are now trying to optimize the stimulation pattern to achieve the best effects, and to improve the design of the electrode array. Further advances in the technology should lead to better control of the stepping and standing processes.
Warm Water Causes Extra-cold Winters
Tapio Schneider, Frank J. Gilloon Professor of Environmental Science and Engineering, and Dr. Yohai Kaspi have found a mechanism that helps explain why average winter temperatures in northern Europe are at least 10 degrees Fahrenheit warmer than similar latitudes on the northeastern coast of the United States. Using computer simulations of the atmosphere, they have found that the warm water off an eastern coast will heat the air above it and lead to the formation of atmospheric waves, drawing cold air from the northern polar region. The cold air forms a plume just to the west of the warm water. In the case of the Atlantic Ocean, this means the frigid air ends up right over the northeastern United States. [Caltech Press Release]