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Largest Biochemical Circuit Built Out of Small Synthetic DNA Molecules

06-02-11

Lulu Qian, Senior Postdoctoral Scholar in Bioengineering, and colleagues including Erik Winfree, Professor of Computer Science, Computation and Neural Systems, and Bioengineering, have built the most complex biochemical circuit ever created from scratch made with DNA-based devices in a test tube that are analogous to the electronic transistors on a computer chip."We're trying to borrow the ideas that have had huge success in the electronic world, such as abstract representations of computing operations, programming languages, and compilers, and apply them to the biomolecular world," says Dr. Qian. [Caltech Press Release]

Tags: EE research highlights health CMS Erik Winfree Lulu Qian postdocs

Converting Heat into Electricity in Space and on Earth - High-Performance Bulk Thermoelectrics

05-23-11

Jeff Snyder, Faculty Associate in Applied Physics and Materials Science, and colleagues have developed a thermoelectric material that might be able to operate off nothing more than the heat of a car's exhaust. "You'll see applications wherever there's a solid-state advantage," Snyder predicts. "One example is the charging system. The electricity to keep your car's battery charged is generated by the alternator, a mechanical device driven by a rubber belt powered by the crankshaft. You've got friction, slippage, strain, internal resistance, wear and tear, and weight, in addition to the mechanical energy extracted to make the electricity. Just replacing that one subsystem with a thermoelectric solution could instantly improve a car's fuel efficiency by 10 percent." [Caltech Press Release]

Tags: APhMS energy research highlights Jeff Snyder

Stimulating Electrode Array Assists Paraplegic Man to Stand and Move Legs Voluntarily

05-20-11

Joel W. Burdick, Professor of Mechanical Engineering and Bioengineering, and colleagues including Yu-Chong Tai, Professor of Electrical Engineering and Mechanical Engineering, have used a stimulating electrode array to assist a paralyzed man to stand, step on a treadmill with assistance, and, over time, to regain voluntary movements of his limbs. Using a combination of experimentation, computational models of the array and spinal cord, and machine-learning algorithms, Professor Burdick and his colleagues are now trying to optimize the stimulation pattern to achieve the best effects, and to improve the design of the electrode array. Further advances in the technology should lead to better control of the stepping and standing processes. 

Tags: EE research highlights MedE health Yu-Chong Tai MCE Joel Burdick

Experiments Settle Long-Standing Debate about Mysterious Array Formations in Nanofilms

05-19-11

Sandra M. Troian, Professor of Applied Physics, Aeronautics, and Mechanical Engineering, and colleagues' experiments have confirmed which of three possible mechanisms is responsible for the spontaneous formation of three-dimensional (3-D) pillar arrays in nanofilms (polymer films that are billionths of a meter thick). "My ultimate goal is to develop a suite of 3-D lithographic techniques based on remote, digital modulation of thermal, electrical, and magnetic surface forces," Troian says. Confirmation of the correct mechanism has allowed her to deduce the maximum resolution or minimum feature size ultimately possible with these patterning techniques. [Caltech Press Release]

Tags: APhMS research highlights GALCIT MCE Sandra Troian

Strong, Tough, and Now Cheap: New Way to Process Metallic Glass

05-12-11

William L. Johnson, Ruben F. and Donna Mettler Professor of Engineering and Applied Science, and his team of researchers have developed a new technique that allows them to make metallic-glass parts utilizing the same inexpensive processes used to produce plastic parts. "We've taken the economics of plastic manufacturing and applied it to a metal with superior engineering properties,” Professor Johnson says. "We end up with inexpensive, high-performance, precision net-shape parts made in the same way plastic parts are made—but made of a metal that's 20 times stronger and stiffer than plastic.” [Caltech Press Release]

Tags: APhMS research highlights William Johnson Metallic Glass

Warm Water Causes Extra-cold Winters

03-30-11

Tapio Schneider, Frank J. Gilloon Professor of Environmental Science and Engineering, and Dr. Yohai Kaspi have found a mechanism that helps explain why average winter temperatures in northern Europe are at least 10 degrees Fahrenheit warmer than similar latitudes on the northeastern coast of the United States. Using computer simulations of the atmosphere, they have found that the warm water off an eastern coast will heat the air above it and lead to the formation of atmospheric waves, drawing cold air from the northern polar region. The cold air forms a plume just to the west of the warm water. In the case of the Atlantic Ocean, this means the frigid air ends up right over the northeastern United States. [Caltech Press Release]

Tags: research highlights ESE Tapio Schneider

How an Idea Becomes a Business

03-29-11

Students in Ken Pickar's course Entrepreneurial Development (E 102) have the opportunity to identify a technology currently under study at Caltech and develop a business plan for it. The ideas used by the students this year included a solid-state memory technology developed by Jehoshua (Shuki) Bruck, Gordon and Betty Moore Professor of Computation and Neural Systems and Electrical Engineering. In this business plan the students proposed targeting Netflix and other high-volume streaming content providers. Another team pinpointed a new market for the vertical wind turbines of John O. Dabiri, Professor of Aeronautics and Bioengineering. A third team pitched a noninvasive method for breaking up arterial plaques using the concentrated-acoustic-pulse technology developed by Chiara Daraio, Professor of Aeronautics and Applied Physics. [Caltech Feature]

Tags: APhMS EE research highlights Chiara Daraio GALCIT Jehoshua Bruck John Dabiri Ken Pickar

Professor Blanquart Receives NSF CAREER Award

02-25-11

Guillaume Blanquart, Assistant Professor of Mechanical Engineering, has been awarded the National Science Foundation's (NSF) Faculty Early Career Development (CAREER) Award for his proposal entitled "Towards understanding and modeling turbulent buoyant flows". The aim of the project is to understand the complex interactions between turbulent fluid mechanics and Rayleigh-Taylor instabilities. These phenomena commonly occur in nature such as in supernova explosions, under water hot-vents, and fires. They are also encountered in many engineering applications such as in Inertial Confinement Fusion.

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Tags: honors research highlights MCE NSF CAREER Guillaume Blanquart NSF

Professor Daraio Named Sloan Research Fellow

02-16-11

Congratulations to Chiara Daraio, Professor of Aeronautics and Applied Physics, for receiving a 2011 Sloan Research Fellowship. The Sloan Research Fellowships are awarded yearly to 118 researchers in recognition of distinguished performance and a unique potential to make substantial contributions to their field.[Caltech Release]

Tags: APhMS honors Chiara Daraio GALCIT Sloan Research Fellowship

Professors Rosakis and Hoffmann Elected to the National Academy of Engineering

02-08-11

Ares J. Rosakis, Theodore von Kármán Professor of Aeronautics and Professor of Mechanical Engineering, and Michael R. Hoffmann, James Irvine Professor of Environmental Science have been elected to the National Academy of Engineering (NAE). Professor Rosakis was elected for discovery of intersonic rupture, contributions to understanding dynamic failure, and methods to determine stresses in thin-film structures. Professor Hoffmann was elected for oxidative treatment technologies for the removal of organic and inorganic contaminants from water.

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Tags: honors GALCIT MCE ESE Ares Rosakis National Academy of Engineering Michael Hoffmann