Paul Rothemund Places Molecule-Scale Devices in Precise Orientation
02-22-21
Paul Rothemund, Research Professor of Bioengineering, Computing and Mathematical Sciences, and Computation and Neural Systems, has developed a technique that allows him to precisely place microscopic devices formed from folded DNA molecules in not only a specific location but also in a specific orientation. This method for precisely placing and orienting DNA-based molecular devices may make it possible to use these molecular devices to power new kinds of chips that integrate molecular biosensors with optics and electronics for applications such as DNA sequencing or measuring the concentrations of thousands of proteins at once. [Caltech story]
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A Microscopic Glowing Van Gogh
07-12-16
Paul Rothemund, Research Professor of Bioengineering, Computing and Mathematical Sciences, and Computation and Neural Systems, and colleagues have developed a technique that allows manmade DNA shapes to be placed wherever desired; to within a margin of error of just 20 nanometers. This technique removes a major hurdle for the large-scale integration of molecular devices on chips. As a demonstration of the technique’s capabilities the group has created one of the world's smallest reproductions of Vincent van Gogh's The Starry Night. [Caltech story]
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Programmed to Fold: RNA Origami
08-20-14
Paul Rothemund, Senior Research Associate in Bioengineering, Computer Science, and Computation and Neural Systems, and colleagues have fabricated complicated shapes from DNA's close chemical cousin, RNA. "RNA origami is still in its infancy," says Rothemund. "Nevertheless, I believe that RNA origami, because of their potential to be manufactured by cells, and because of the extra functionality possible with RNA, will have at least as big an impact as DNA origami." [Caltech Release]
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DNA Origami Nanoscale Breadboards for Carbon Nanotube Circuits
11-10-09
Hareem T. Maune, a graduate student studying carbon nanotube physics, and Si-ping Han, a graduate student investigating the interactions between carbon nanotubes and DNA have developed DNA origami nanoscale breadboards for carbon nanotube circuits. "This collaborative research project is evidence of how we at Caltech select the top students in science and engineering and place them in an environment where their creativity and imagination can thrive," says Ares Rosakis, chair of the Division of Engineering and Applied Science at Caltech and Theodore von Kármán Professor of Aeronautics and Professor of Mechanical Engineering. The work of these students was supervised by: Erik Winfree, Associate Professor of Computer Science, Computation and Neural Systems, and Bioengineering; William A. Goddard III, Charles and Mary Ferkel Professor of Chemistry, Materials Science, and Applied Physics; Paul W.K. Rothemund, Senior Research Associate, and Marc Bockrath, Associate Professor of Physics at University of California Riverside. [Caltech Press Release]
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Paul Rothemund and Colleagues Use Self-Assembled DNA Scaffolding to Build Tiny Circuit Boards
08-18-09
Dr. Paul Rothemund, Senior Research Associate in Bioengineering, Computer Science, and Computation and Neural Systems, and colleagues have developed a new technique to orient and position self-assembled DNA shapes and patterns--or "DNA origami"--on surfaces that are compatible with today's semiconductor manufacturing equipment. They "have removed a key barrier to the improvement and advancement of computer chips. They accomplished this through the revolutionary approach of combining the building blocks for life with the building blocks for computing," said Professor Ares Rosakis, Chair of Division of Engineering and Applied Science and Theodore von Kármán Professor of Aeronautics and Mechanical Engineering. [Caltech Press Release]
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