Pushing Microscopy Beyond Standard Limits
07-29-13
Changhuei Yang, Professor of Electrical Engineering and Bioengineering, and colleagues have shown how to make cost-effective, ultra-high-performance microscopes. The final images produced by their new system contain 100 times more information than those produced by conventional microscope platforms. And building upon a conventional microscope, their new system costs only about $200 to implement. This new method could have wide applications not only in digital pathology but also in everything from hematology to wafer inspection to forensic photography. [Caltech Release]
Tags:
EE
research highlights
Changhuei Yang
MedE
health
Counting White Blood Cells at Home
03-28-13
Yu-Chong Tai, Professor of Electrical Engineering and Mechanical Engineering, and colleagues have developed a portable device to count white blood cells that needs less than a pinprick's worth of blood and takes just minutes to run. The heart of the new device is a 50-micrometer-long transparent channel made out of a silicone material with a cross section of only 32 micrometers by 28 micrometers—small enough to ensure that only one white blood cell at a time can flow through the detection region. The stained blood sample flows through this microfluidic channel to the detection region, where it is illuminated with a laser, causing it to fluoresce. [Caltech Release]
Tags:
EE
research highlights
MedE
health
Yu-Chong Tai
MCE
Disease Diagnosis at the Touch of a Button
02-25-13
Axel Scherer, Bernard Neches Professor of Electrical Engineering, Applied Physics and Physics, and colleagues have built a new version of a polymerase chain reaction (PCR) device, which generates many copies of a pathogenic nucleic acid, allowing the infection to be detected. The device is the result of nearly 10 years of research at Caltech. In 2004, Scherer, a leader in the field of microfluidics, and George Maltezos were investigating how to manipulate biological fluids on a chip. While this was an interesting engineering problem, Maltezos began to wonder how he could apply the microfluidic techniques that he was perfecting to real-world problems. Then the H5N1 bird flu pandemic erupted in Asia, and the team had their real-world problem. [Caltech Release]
Tags:
APhMS
EE
MedE
health
Axel Scherer
George Maltezos
A New Tool for Secret Agents—And the Rest of Us
12-10-12
Ali Hajimiri, Thomas G. Myers Professor of Electrical Engineering, and Postdoctoral Scholar in Electrical Engineering, Kaushik Sengupta, have developed tiny inexpensive silicon microchips that generate terahertz (THz) waves that fall into a largely untapped region of the electromagnetic spectrum and that can penetrate a host of materials without the ionizing damage of X-rays. When incorporated into handheld devices, the new microchips could enable a broad range of applications in fields ranging from homeland security to wireless communications to health care, and even touchless gaming. "This extraordinary level of creativity, which has enabled imaging in the terahertz frequency range, is very much in line with Caltech's long tradition of innovation in the area of CMOS technology," says Chair Ares Rosakis. "Caltech engineers, like Ali Hajimiri, truly work in an interdisciplinary way to push the boundaries of what is possible." [Caltech Release]
Tags:
EE
energy
research highlights
MedE
health
Ali Hajimiri
Kaushik Sengupta
postdocs
3-D Dentistry
11-30-12
Morteza Gharib, Hans W. Liepmann Professor of Aeronautics and Professor of Bioinspired Engineering as well as Caltech Vice Provost, has designed a handheld device, that has three apertures which take a picture of the tooth at the same time, but from different angles. The three images are then blended together using a computer algorithm to construct a 3-D image. His imaging innovation will ease your trip to the dentist and may soon energize home entertainment systems too. "Professor Gharib is as brilliant a scientist as he is an engineer and inventor," says Chair Ares Rosakis. "I think that's what we have to do to look at humanity's big problems: we have to be ready to act as pure scientists when we observe and discover as well as act as practical engineers when we invent and apply. This continuous interplay happens at Caltech better than at other institutions." [Caltech Release]
Tags:
GALCIT
MedE
health
Morteza Gharib
Progress for Paraplegics
10-25-12
Joel W. Burdick, Richard L. and Dorothy M. Hayman Professor of Mechanical Engineering and Bioengineering, and Yu-Chong Tai, Professor of Electrical Engineering and Mechanical Engineering, are developing new technologies to expand their research which has enabled a paraplegic man to stand and move his legs voluntarily. The team has until now used intelligent guesswork to determine which stimuli might work best. But soon, using a new algorithm developed by Professor Burdick, they will be able to rely on a computer to determine the optimum stimulation levels, based on the patient's response to previous stimuli. This would allow patients to go home after the extensive rehab process with a system that could be continually adjusted by computer. [Caltech Release] [ENGenious Progress Report]
Tags:
EE
research highlights
MedE
health
Yu-Chong Tai
MCE
Joel Burdick
Developing the Next Generation of Microsensors
10-19-12
Oskar J. Painter, Professor of Applied Physics; Executive Officer for Applied Physics and Materials Science; and Co-Director, Kavli Nanoscience Institute, and colleagues have engineered a microscale optical accelerometer. In addition to transforming consumer electronics, such sensors could help with oil and gas exploration deep within the earth, could improve the stabilization systems of fighter jets, and could even be used in some biomedical applications where more traditional sensors cannot operate. "Professor Painter's research in this area nicely illustrates how the Engineering and Applied Science faculty at Caltech are working at the edges of fundamental science to invent the technologies of the future," says Chair Ares Rosakis. [Caltech Release]
Tags:
APhMS
energy
health
Oskar Painter
