A Swiss Army Knife for Genomic Data
04-05-21
A good way to find out what a cell is doing—whether it is growing out of control as in cancers, or is under the control of an invading virus, or is simply going about the routine business of a healthy cell—is to look at its gene expression. Lior Pachter, Bren Professor of Computational Biology and Computing and Mathematical Sciences, has developed a complex software tool that enables the processing of large sets of genomic data in about 30 minutes, using the computing power of an average laptop. Like a Swiss Army knife, the tool can be used in myriad ways for different biological needs, and will help ensure the reproducibility of scientific studies. "The interdisciplinarity of our team was crucial to conceiving of and executing this project," says Pachter. "There are people in the lab who are computer scientists, biologists, engineers. Sina Booeshaghi is in the mechanical engineering department and brings the perspective of his design background and engineering." [Caltech story]
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CMS
Lior Pachter
Sina Booeshaghi
Astronomers Image Magnetic Fields at the Edge of M87's Black Hole
03-24-21
The Event Horizon Telescope (EHT) collaboration, which produced the first-ever image of a black hole, revealed a new view of the massive object at the center of the M87 galaxy: a picture of its polarized light. This is the first time astronomers have been able to measure polarization, a signature of magnetic fields, this close to the edge of a black hole. "We are now able to see a different dimension of the light circling the M87 black hole," says Katie Bouman, Assistant Professor of Computing and Mathematical Sciences, Electrical Engineering and Astronomy, Rosenberg Scholar, and co-coordinator of the EHT Imaging Working Group. "The image we reconstructed earlier showed us how bright the light was around the black hole shadow. This image is telling us about the direction of that light." [Caltech story]
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CMS
Katie Bouman
Untangling the Heat Paradox Along Major Faults
03-12-21
Nadia Lapusta, Lawrence A. Hanson, Jr., Professor of Mechanical Engineering and Geophysics, and graduate student Valère Lambert, seek to explain the size of the forces acting on "mature faults"—long-lived faults along major plate boundaries like the San Andreas Fault in California—in an effort to better understand the physics that drive the major earthquakes that occur along them. Understanding the physics that govern major earthquakes on different types of faults will help generate more accurate forecasts for earthquake threats. "We have a lot of data from large earthquakes along subduction zones, but the last really major earthquakes along the San Andreas were the magnitude-7.9 Fort Tejon quake in 1857 and the magnitude-7.9 San Francisco Earthquake in 1906, both of them before the age of modern seismic networks," Lapusta says. [Nature article] [Caltech story]
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Nadia Lapusta
Valère Lambert
Professor Bouman Featured in Inverse Magazine
03-10-21
Katie Bouman, Assistant Professor of Computing and Mathematical Sciences, Electrical Engineering and Astronomy; Rosenberg Scholar, was featured in Inverse Magazine as one of the astronomers who captured the first image of a black hole. In 2019, Bouman and a group of more than 200 astronomers from all over the world managed the inconceivable: They captured the first image of a black hole, rendering the invisible visible. "Ideally, to see a black hole, we would need a telescope the size of the entire Earth," says Bouman. "We had to come up with a computational telescope that size." [Inverse article]
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CMS
Katie Bouman
New Insight into Nonlinear Optical Resonators Unlocks Door to Numerous Potential Applications
02-25-21
Devices known as optical parametric oscillators are among the widely used nonlinear resonators in optics; they are "nonlinear" in that there is light flowing into the system and light leaking out, but not at the same wavelengths. Though these oscillators are useful in a variety of applications, including in quantum optics experiments, the physics that underpins how their output wavelength, or spectrum, behaves is not well understood. "When you add strong nonlinearity to resonators, you enter what we call a 'rich physics regime,'" says Alireza Marandi, Assistant Professor of Electrical Engineering and Applied Physics. "'Rich' in physics terms usually means complicated and hard to use, but we need nonlinearities to create useful functionalities such as switching for computing." To be able to make full use of nonlinear optical resonators, researchers want to be able to understand and model the physics that underpin how they work. Marandi and his colleagues recently uncovered a potential way to engineer those rich physics, while discovering phase transitions in the light that is generated by the resonators. [Caltech story]
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Alireza Marandi
Paul Rothemund Places Molecule-Scale Devices in Precise Orientation
02-22-21
Paul Rothemund, Research Professor of Bioengineering, Computing and Mathematical Sciences, and Computation and Neural Systems, has developed a technique that allows him to precisely place microscopic devices formed from folded DNA molecules in not only a specific location but also in a specific orientation. This method for precisely placing and orienting DNA-based molecular devices may make it possible to use these molecular devices to power new kinds of chips that integrate molecular biosensors with optics and electronics for applications such as DNA sequencing or measuring the concentrations of thousands of proteins at once. [Caltech story]
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CMS
Paul Rothemund
KNI
CNS
Student-Led Moon Dust Shield Team Named Finalist in NASA Competition
02-16-21
As astronauts walk across the moon, land spacecraft on its surface, drive lunar rovers around, or complete other astronaut tasks, they kick up the dust, and that is a problem because it can cause premature wear on mechanical parts, damage to seals, and may pose a health risk for the people breathing it in. "The sun is shining directly on these particles and giving them an electric charge," says third-year Caltech undergraduate student Luis Pabon. "This causes it to stick to the astronaut's suit or to any sensors or cameras that you put out on the moon." The Caltech team's invention, named Habitat Orientable & Modular Electrodynamic Shield (HOMES), tackles the problem of moon dust entering a potential lunar habitat and wreaking havoc within. [Caltech story]
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GALCIT
MCE
Luis Pabon
Caltech and NTT Research Launch Collaboration to Develop World’s Fastest Coherent Ising Machine
01-25-21
Researchers from Caltech and NTT Research are collaborating to develop a high-speed Coherent Ising Machine (CIM). A CIM is a network of optical parametric oscillators (OPOs) programmed to solve problems that have been mapped to an Ising model, which is a mathematical abstraction of magnetic systems composed of competitively interacting spins, or angular momentums of fundamental particles. The principal investigator at Caltech for this four-and-a-half-year joint project is Kerry Vahala, Ted and Ginger Jenkins Professor of Information Science and Technology and Applied Physics; Executive Officer for Applied Physics and Materials Science. “We are delighted at the prospect of working with Professor Vahala to develop an extremely small and high-speed CIM,” said NTT Research PHI Lab Director, Yoshihisa Yamamoto. “This work will advance our understanding of the CIM’s capabilities, map well with ongoing and related work with other institutions, provide new demonstrations of this awesomely powerful new information system and, we hope, set standards for the CIM’s speed and size.” [NTT Research story] [Business Wire story]
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Kerry Vahala
KNI
