Changhuei Yang Develops "Microscope on a Chip"
Changhuei Yang, Assistant Professor of Electrical Engineering and Bioengineering, and colleagues have turned science fiction into reality with their development of a super-compact high-resolution microscope, small enough to fit on a finger tip. This "microscopic microscope" operates without lenses but has the magnifyingpower of a top-quality optical microscope, can be used in the field to analyze blood samples for malaria or check water supplies for giardia and other pathogens, and can be mass-produced for around $10.
Chemistry of Airborne Particulate—Lung Interactions Revealed by Agustin Colussi and Colleagues
Agustin J. Colussi, senior research associate in environmental science and engineering, and colleagues have found that airborne particulates impair the lungs' naturaldefenses against ozone. Their research focused on what happens when air meets the thin layer of antioxidant-rich fluid that covers our lungs, protecting them from ozone, an air pollutant that pervades major cities. "We found new chemistry at the interfaces separating gases from liquids using a technique that continuously monitors the composition of these interfaces," Colussi says. Under normal physiological conditions, ascorbic acid instantly scavenges ozone, generating innocuous byproducts. However, the researchers discovered that when the fluid is acidic, a pathological condition found in asthmatics, ascorbic acid instead reacts with ozone to form potentially harmful compounds called ozonides.
Michael Elowitz Named HHMI Investigator
Michael Elowitz, Assistant Professor of Biology and Applied Physics and a Bren Scholar, has been named a Howard Hughes Medical Institute (HHMI) investigator. Elowitz is fundamentally interested in how cells' own genetic circuits dictate what type of cells they become. In work that overturned the steadfastnotion that genes and networks of genes operate in a predictable and fixed fashion, he and his colleagues showed that key properties of the cell, like how actively it turns out different proteins, are intrinsically random. To show that randomness is used to more accurately control the shapes and patterns that make organisms work, Elowitz is turning to larger and more complex animal cells. "I'm grateful to HHMI for the amazing opportunity this appointment presents to focus as much as possible on research. The funds will enable us to explore new directions, especially allowing us to expand approaches we've previously developed primarily in bacteria to mammalian cells." [Caltech Press Release]